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Problematika infekcij z virusom herpes simplex (HSV) v slovenski populaciji glede na genitalne manifestacije (Slovene)
Problematika infekcij z virusom herpes simplex (HSV) v slovenski populaciji glede na genitalne manifestacije
Start: 1/1/1997
End: 12/31/1999
Homepage: http://sicris.izum.si/search/prj.aspx?lang=slv&id=522

Project Status History
unknown 1/1/1997
 
Keywords
genital herpes, antibodies to herpes simplex virus (HSV) type 1 and type 2, epidemiologic study
genitalni herpes, protitelesa proti herpes simpleks virusoma tip1 in tip 2, epidemiološka študija

Abstract
We intend to evaluate the epidemiology of herpes simplex type1 and type 2 in Slovene population. Therefore two groups were formed; in the first (the STD group) are patients treated at the outpatient clinics for sexually transmitted diseases (STDs) in Ljubljana and Maribor. The second group (the control group) is formed from persons whose eventual disease is in no way connected with sexually transmitted infections and who have a negative history of sexually tramsmitted deseases. The control group is adjusted to the STD group regarding the age and sex of the attendees. 221 sera were tested and 200 results were statistically analysed - 100 from each group. Blood samples were collected and tested at the Institute for Microbiology and Immunology of Medical Faculty (MF) Ljubljana. For detection of IgG antibodies against HSV type 1 the Behring Enzygnost anti HSV (IgG) reagents and for detection of antibodies against HSV type 2 Virotech ELISA Testkit Herpes simplex 2 (for IgG detection) were used. The following results were obtained: the prevalence of IgG antibodies against HSV type 1 was 91 % in the STD group and 82 % in the control group. The prevalence of IgG antibodies against HSV type 2 was 69 % in the STD group and 57 % in the control group.High titers of antibodies to HSV type 2 in both groups and especially the absence of statistically significant difference between them induced us to reexamine a number of sera with the ELISA type specific test for HSV type 2 from the Gull Laboratories. At the reexamination essentially lower percentage of anti HSV type 2 positive sera were obtained: in the STD group roughly 17 % and in the control group only a few percents.
Naš namen je oceniti prekuženost slovenske populacije s herpes simpleks virusoma tip1 in 2. V ta namen smo oblikovali dve skupini: v prvi (SPB skupina) so bolniki ambulant za spolno prenosljive bolezni v Ljubljani in Mariboru, v drugi pa osebe, katerih ev. obolenje ni ne v neposredni ne v posredni vzročni povezavi s spolno prenosljivo okužbo in ki v anamnezi nimajo podatka o preboleli spolno prenosljivi bolezni (kontrolna skupina). Kontrolna skupina je po spolu in starosti prilagojena SPB skupini. Vzorce odvzete krvi so zbirali in testirali na Inštitutu za mikrobiologijo in imunologijo Medicinske fakultete (MF) v Ljubljani. Za ugotavljanje prisotnosti IgG protiteles proti HSV tip 1 so uporabljali reagente Behring Enzygnost anti HSV (IgG), za protitelesa proti HSV tip 2 pa Virotech ELISA Testkit Herpes simplex 2 (for IgG detection). Pregledanih je bilo 221 vzorcev, statistično obdelanih pa 200 vzorcev - po 100 iz vsake skupine. Ugotovljene so bile naslednje prevalence: IgG protitelesa proti HSV tip 1 so bila v SPB skupini prisotna v 91 %, v kontrolni skupini pa v 82 %. IgG protitelesa proti HSV tipa 2 so bila v SPB skupini prisotna v 69 %, v kontrolni skupini pa v 57 %. Rezultati serologije na HSV tip2 so nas navedli na misel, da gre za metodološko napako, kar je bilo potrjeno, ko so na Inštitutu za mikrobiologijo in imunologijo MF v Ljubljani del serumov ponovno testirali z ELISA tipsko specifičnim testom firme Gull Laboratories. Tokrat so bili okvirni rezultati bistveno drugačni; protitelesa proti HSV tip 2 so bila v SPB skupini prisotna v 17 %, v kontrolni skupini pa le v nekaj odstotkih.

 
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