|This project aims at the investigation of the circadian clocks in single cells and in humans. Behaviour, physiology, and biochemistry are temporally structured and characterised by daily oscillations. These cycles are not simply driven by external changes as light/dark or warm/cold. They are controlled by endogenous clocks that are prevalent in the most diverse organisms, from cyanobacteria to humans. These circadian clocks are synchronised to the outside world by a process called entrainment, which is generated by rhythmic environmental signals, called ’ZEITGEBERS'. EUCLOCK researchers are precisely interested in how these circadian clocks are synchronised to their specific cyclic environment.
Furthermore, new genetic components that control the circadian clock and its entrainment will be identified in animals and in humans.
New tools will be developed and new circadian model organisms will be explored. These will enable the field of chronobiology to exploit the advantages of systems biology research on circadian timing to be performed and integrated at the level of the genome, the proteome, and the metabolome.
The innovations of EUCLOCK are predestined to shape the future of circadian research.