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Novel sources of actinomycete diversity for detection of antimicrobial agents with pharmaceutical applications

Acronym: ACTAPHARM
Start: 10/1/2001
End: 9/30/2004
Homepage: http://cordis.europa.eu/data/PROJ_FP5/ACTIONeqDndSESSIONeq112482005919ndDOCeq1981ndTBLeqEN_PROJ.htm

Project Status History
completed10/1/2001
 
Abstract
Novel anti-microbial agents are needed to overcome problems of resistance and provide protection against infection. The control of microbial growth is also an essential part of product preservation in the cosmeceutical industry. Despite high throughput screening the discovery rate of novel ant microbial compounds has declined. We aim to reverse this trend by exploiting biodiversity within the uncultured microbial populations in the environment and clone habitat met genomes using bacterial artificial chromosomes. To evaluate the cloning procedure habitat diversity will be analysed at the functional and taxonomic level. Targeted assays will identify ant microbial activities of clones for use in control of infections, as transferral applications and as preservatives for pharmaceuticals. Thus we aim to combine chemical novelty with novelty in application.

 
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CORDIS FP5+FP6
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European Research
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