|The primary focus of LIPGEN is the interaction of nutrients and genotype in the metabolic syndrome. With access to a large prospective cohort followed biannually for 7 years and with hard clinical and nutritional data, a unique opportunity exists to determine diet-gene interaction in the development of the metabolic syndrome. To ascertain the responsiveness to dietary fat modification, large multi-centre dietary intervention study will examine how diets varying in both fat content and composition influence insulin sensitivity and other aspects of the metabolic syndrome including gene intervantions. Parallel studies at molecular, cell and whole body level will investigate mechanisms linking dietary fat and the metabolic syndrome. A key aim of the animal nutrition component is to reduce saturated fat and increasing monounsaturated fatty acids (MUFA) and n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), whilst avoiding an increase in trans fatty acid intake. The objective of the plant biotechnology section is in the area of metabolic engineering of linseed; using marine algal genes to transgenic ally reconstitute the LC-PUFA biosynthetic pathway. These studies will be accompanied by a detailed economic analysis of the health costs of the metabolic syndrome across the EU and the implications of individual drug versus population nutrition intervention. It will also look at the cost implications of implementing the new animal nutrition and plant biotechnologies in primary food production. Consumer attitudes to new agro-food technologies and the use of genomic in personalized nutrition will also be examined. Finally, a demonstrations project will show how in practice these fat-modified foods can be created and be used to reduce the risk factors of the metabolic syndrome. A major dissemination programme will target consumers, industry, opinion formers and Sees.